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Mechanism of Antioxidative Activity of Fluvastatin-Determination of the Active Position

Mechanism of Antioxidative Activity of Fluvastatin-Determination of the Active Position

T Nakamura, H Nishi, Y Kokusenya, K Hirota, Y Miura

Chem Pharm Bull (Tokyo). 2000 Feb;48(2):235-7.

PMID: 10705511

Abstract:

In order to clarify the mechanism of action for the antioxidative activity of fluvastatin sodium (FLV, (+/-)-sodium (3RS, 5RS, 6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3, 5-dihydroxy-6-heptanoate) and its derivatives, reaction of the corresponding methyl ester of FLV with di-tert-butyl diperoxyoxalate was examined, and the corresponding keto derivative was isolated from the reaction mixture. On the basis of this result, it was concluded that the active site is the allylic carbon conjugated with the indole ring.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5454284	Butyl heptanoate		5454-28-4	Price

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