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[Mechanism of BVT.2733 and Pioglitazone in the Improvement of Insulin Resistance]

[Mechanism of BVT.2733 and Pioglitazone in the Improvement of Insulin Resistance]

Yu Xie, Ting Zhu, Yi Zhong, Juan Liu, Jing Yu, Juan-ming Zha, Wen-juan DI, Guo-xian Ding

Zhonghua Nei Ke Za Zhi. 2008 Nov;47(11):938-41.

PMID: 19080239

Abstract:

Objective:
To investigate the mechanism of BVT.2733 on insulin resistance, by using diet-induced obese (DIO) mice model.
Methods:
After having been balanced for 3 days, the C57BL/6J mice were randomly divided into a normal diet group and a high-fat diet (HFD) group. After 20 weeks, the obese mice were further randomly divided into an obese control group, a BVT.2733 group and a pioglitazone (PGZ) group and they were orally administered with placebo, BVT.2733 and PGZ separately for two weeks. Adiponectin and leptin mRNA expression levels from adipose tissue were analyzed with real-time quantitative PCR. The levels of plasma glucose, serum insulin and adiponectin were measured with biochemical technology, radioimmunoassay and ELISA. Adipocyte sizes were observed with immunohistochemistry.
Results:
The body weight, plasma glucose and serum insulin levels raised (P < 0.05) in the HFD group and the adipocyte sizes were bigger. Serum insulin levels significantly reduced (P < 0.05) and adipocyte sizes reduced, while plasma adiponectin level raised (P < 0.01) in the two treatment groups as compared with those in obese controls. Both the mRNA expressions of adiponectin and leptin upregulated (P < 0.05) in the PGZ group, but their expressions in the BVT.2733 group did not alter significantly. The body weight of the mice reduced significantly in the BVT.2733 group.
Conclusion:
BVT.2733 can reduce body weight significantly and improve insulin resistance, but cannot influence the expression of adipocytokines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP376640414	BVT.2733		376640-41-4	Price

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