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Mechanism of Colchicine Impairment on Learning and Memory, and Protective Effect of CGP36742 in Mice

Z Yu, G Cheng, B Hu

Brain Res. 1997 Mar 7;750(1-2):53-8.

PMID: 9098529

Abstract:

Fourteen days after hippocampal microinfusion with colchicine (COL), learning and memory ability of mice was significantly impaired, while glutamate (Glu), gamma-aminobutyric acid (GABA), Glu/GABAB and GABAB receptor levels in the cortex and/or the hippocampus were significantly changed. After treatment with a GABAB receptor antagonist, CGP36742, learning and memory impairment caused by COL could be significantly improved, and the above indices in brain regions reversed. These results suggest GABAB antagonists may have therapeutic value in the treatment of Alzheimer's disease.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP123690788 CGP36742 CGP36742 123690-78-8 Price
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