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[Mechanisms of Realization of Protective Effect of Miliacin During Experimental Salmonella Infection: Effect of Endotoxinemia and Cytokine Production]

[Mechanisms of Realization of Protective Effect of Miliacin During Experimental Salmonella Infection: Effect of Endotoxinemia and Cytokine Production]

B A Frolov, I N Chaĭnikova, Iu V Filippova, A I Smoliagin, T V Panfilova, A D Zheleznova

Zh Mikrobiol Epidemiol Immunobiol. Sep-Oct 2014;(5):8-12.

PMID: 25536765

Abstract:

Aim:
Evaluate the effect of miliacin on the intensity of endotoxinemia and features of cytokine production in experimental salmonella infection.
Materials and methods:
The studies were carried out in 128 male mice (CBAxC57Bl6)F1 divided into 4 groups: I--intact; II--infected; III--infected after administration of miliacin solvent: tween-21; IV--infected after administration of miliacin. Determination of the endotoxin in blood plasma was carried out by using chromogenic LAL-test. Cytokine production was studied in splenocyte culture by EIA method.
Results:
Miliacin reduced the intensity of endotoxinemia in mice of group IV. Salmonella infection increased spontaneous (IFNγ) and induced (IL-12, IFNγ, IL-17) cytokine production. Miliacin ensured the most significant increase of spontaneous IL-10, IL-12 and IFNγ production compared with groups II and III. At the same time it limited the increase of induced IL-17 production compared with groups II and III.
Conclusion:
Protective effect of miliacin is determined by the reduction of endotoxinemia, mobilization of Th-1 response, stimulation of IL-10 production and limitation of IL-17 participation in the development of the inflammatory reaction.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5945459	Miliacin		5945-45-9	Price

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