Home
Resources
Publications
Medicinal Attributes of 1,2,3-triazoles: Current Developments

Medicinal Attributes of 1,2,3-triazoles: Current Developments

Divya Dheer, Virender Singh, Ravi Shankar

Bioorg Chem. 2017 Apr;71:30-54.

PMID: 28126288

Abstract:

1,2,3-Triazoles are important five-membered heterocyclic scaffold due to their extensive biological activities. This framework can be readily obtained in good to excellent yields on the multigram scale through click chemistry via reaction of aryl/alkyl halides, alkynes and NaN3 under ambient conditions. It has been an emerging area of interest for many researchers throughout the globe owing to its immense pharmacological scope. The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors (celecoxib, pyrazofurin), HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials. The emphasis has been given on the major advancements in the medicinal prospectus of this pharmacophore for the period during 2008-2016.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30868305	Pyrazofurin		30868-30-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: