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Mesostructured Silica and Aluminosilicate Carriers for Oxytetracycline Delivery Systems

Mesostructured Silica and Aluminosilicate Carriers for Oxytetracycline Delivery Systems

D Berger, S Nastase, R A Mitran, M Petrescu, E Vasile, C Matei, T Negreanu-Pirjol

Int J Pharm. 2016 Aug 30;510(2):524-31.

PMID: 26861688

Abstract:

Oxytetracycline delivery systems containing various MCM-type silica and aluminosilicate with different antibiotic content were developed in order to establish the influence of the support structural and textural properties and aluminum content on the drug release profile. The antibiotic molecules were loaded into the support mesochannels by incipient wetness impregnation method using a drug concentrated aqueous solution. The carriers and drug-loaded materials were investigated by small- and wide-angle XRD, FTIR spectroscopy, TEM and N2 adsorption-desorption isotherms. Faster release kinetics of oxytetracycline from uncalcined silica and aluminosilicate supports was observed, whereas higher drug content led to lower delivery rate. The presence of aluminum into the silica network also slowed down the release rate. The antimicrobial assays performed on Staphylococcus aureus clinical isolates showed that the oxytetracycline-loaded materials containing MCM-41-type mesoporous silica or aluminosilicate carriers inhibited the bacterial development.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1318021	Aluminosilicate, mesostructured		1318-02-1	Price
AP7631869-A	Silica, mesostructured		7631-86-9	Price

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