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Metabolism of 3 Alpha, 7 alpha-dihydroxy-5 Beta-Cholestanoic Acid by Rat Liver in Vivo and in Vitro

Metabolism of 3 Alpha, 7 alpha-dihydroxy-5 Beta-Cholestanoic Acid by Rat Liver in Vivo and in Vitro

J Gustafsson

J Lipid Res. 1979 Feb;20(2):265-70.

PMID: 438665

Abstract:

The metabolism of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid was studied in the bile fistula rats and in preparations from rat liver homogenates. In the bile fistula rats, the main products were chenodeoxycholic acid, alpha-muricholic acid, and beta-muricholic acid. Only small amounts of cholic acid were formed. Incubations of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid with microsomes and NADPH yielded as the main product 3 alpha, 6 beta, 7 alpha-trihydroxy-5 beta-cholestanoic acid. The formation of small amounts of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid was shown. The major product in incubations of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid with microsomes and the 100,000 g supernatant fluid fortified with ATP was identified as 3 alpha, 7 alpha, 24 xi-trihydroxy-5 beta-cholestanoic acid. This compound was converted into chenodeoxycholic acid and its metabolites in the bile fistula rat.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP871125712	4-Propoxy-2,3,5,6-tetrafluorophenylboronic acid		871125-71-2	Price

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