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Metabolism of Chicoric Acid by Rat Liver Microsomes and Bioactivity Comparisons of Chicoric Acid and Its Metabolites

Metabolism of Chicoric Acid by Rat Liver Microsomes and Bioactivity Comparisons of Chicoric Acid and Its Metabolites

Qian Liu, Yutang Wang, ChunXia Xiao, Wanqiang Wu, Xuebo Liu

Food Funct. 2015 Jun;6(6):1928-35.

PMID: 25968347

Abstract:

Chicoric acid has recently become a hot research topic due to its potent bioactivities. However, there are few studies relevant to this acid's pharmacokinetic characteristics and the pharmacological activities of its metabolites. To compare the abilities of chicoric acid and its metabolites in scavenging free radicals and their effects on the viability of 3T3-L1 preadipocytes, an in vitro study of the metabolism of chicoric acid in rat liver microsomes was performed using liquid tandem mass spectrometry (HPLC-MS/MS). The results indicated that caffeic acid and caftaric acid were the hepatic phase I metabolites of chicoric acid. These three compounds had strong capacities for scavenging free radicals and had been demonstrated to increase intracellular ROS levels in 3T3-L1 preadipocytes, thereby reducing cell vitality. Finally, the pharmacological activities of chicoric acid were significantly stronger than those of its metabolites within a certain concentration range.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70831560-A	( −)-Chicoric acid		70831-56-0	Price
AP70831560-B	Chicoric acid		70831-56-0	Price

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