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Metabolism of Hibifolin by Human Intestinal Bacteria

Metabolism of Hibifolin by Human Intestinal Bacteria

Tong-Tong Xu, Xiu-Wei Yang, Bin Wang, Wei Xu, Yu-Ying Zhao, Qing-Ying Zhang

Planta Med. 2009 Apr;75(5):483-7.

PMID: 19235125

Abstract:

Hibifolin, the highest-content bioactive flavonoid of the flowers of Abelmoschus manihot, was incubated with human intestinal bacteria, and four metabolites (1-4) were obtained from the incubated solution by chromatographic methods. The structures of the four metabolites were elucidated as gossypetin 8-O-beta-D-4''-deoxy- Delta(4'')-glucuropyranoside (1), gossypetin (2), quercetin (3), and 8-methoxy-quercetin (4), respectively, on the basis of UV, NMR, and MS data. Metabolite 1 was obtained as a new compound with a specific beta-D-4''-deoxy-Delta(4'')-glucuropyranosyl moiety, which was formed through a unique and novel metabolic pathway that has not been reported previously.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP55366568	Hibifolin		55366-56-8	Price

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