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Metal Ion Levels in Ceramic-On-Ceramic THR With Cobalt-Chrome Modular Necks: Analysis of Cobalt and Chromium Serum Levels in 23 Healthy Hip Patients

Metal Ion Levels in Ceramic-On-Ceramic THR With Cobalt-Chrome Modular Necks: Analysis of Cobalt and Chromium Serum Levels in 23 Healthy Hip Patients

Jan F A Somers, Lieven Dedrye, Sofie Goeminne

Hip Int. 2017 Feb 21;27(1):21-25.

PMID: 27791242

Abstract:

Background:
Modular necks in total hip replacement (THR) can be a source of metal ion release.
Methods:
We measured the level of cobalt (Co) and chromium (Cr) ions in the serum of 23 healthy volunteers with a well-functioning ceramic-on-ceramic THR of a particular design, containing a cobalt-chrome (Co-Cr) stem and a Co-Cr modular neck.
Results:
Average Co in serum was 1,71 µg/l; median Co was 1.50 µg/l. No patient had Co levels higher than 3.70 µg/l. Average Cr level was 0.49 µg/l; in all but one patient Cr was below the detection limit (<0.50 µg/l). Co was higher for varus necks compared to all other subtypes: 2.14 µg/l vs 1.58 µg/l (p<0.05). The same system with Titanium modular necks shows lower Co serum levels: 1.26 µg/l (p<0.01 ). In conclusion, the hybrid THR Profemur Xm® - Procotyle L® with a Co-Cr modular neck on a Co-Cr stem design shows very low Cr ion serum levels in a randomly selected group of well-functioning hip patients.
Conclusions:
Co ion serum levels are low, but significantly higher for 8° varus necks, and Co levels are significantly higher than values of this system with a Titanium modular neck.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248764	Serum Replacement 1 (50×)			Price

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