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Methyl-β-Cyclodextrin /Cetyltrimethyl Ammonium Bromide Synergistic Sensitized Fluorescence Method for the Determination of Levofloxacin

Methyl-β-Cyclodextrin /Cetyltrimethyl Ammonium Bromide Synergistic Sensitized Fluorescence Method for the Determination of Levofloxacin

Qiuyi Ren, Xiashi Zhu

J Fluoresc. 2016 Mar;26(2):671-7.

PMID: 26695946

Abstract:

A novel method of methyl-β-cyclodextrin (methyl-β-CD) and cetyltrimethyl ammonium bromide (CTAB) synergistic sensitized fluorescence analysis to determine levofloxacin (LVFX) was developed. The results were shown that the fluorescence intensity of LVFX was increased a lot in the system of methyl-β-cyclodextrin-CTAB medium. Under the conditions of λ(ex/em )= 330/507 nm and pH 4.5, the linear range and the detection limit for LVFX were found to be 0.040 ~ 4.0 μg/mL and 0.3 ng/mL, respectively. The mechanism of sensitized fluorescence method was discussed by the solubilization capacity and the microenvironment of medium. The proposed method has been applied for the determination of LVFX in eye drops real samples and human serum with satisfactory recovery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12124979	Ammonium bromide		12124-97-9	Price

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