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Methyl Palmitate Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

Methyl Palmitate Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

S Kalemci, A Zeybek, Y S Intepe, A G Uner, T Acar, A Yaylali, S Aksun, C Can, A Gulaydin, R Sütçü

Clin Ter. 2013;164(6):e453-9.

PMID: 24424222

Abstract:

Aim:
The study is aimed to determine the beneficial effects of methyl palmitate (MP) which has antioxidant and anti-inflammatory effects demonstrated on murine model of acute lung injury induced by lipopolysaccharide (LPS).
Materials and methods:
Forty male BALB/C mice were randomly allocated into four groups (n=10, each): control group, methyl palmitate group (300 mg/kg), LPS group, and methyl palmitate -treated groups. Methyl palmitate or vehicle was given with an intraperitoneal administration 1 h before an intratracheal instillation of LPS (5 mg/kg). The severity of pulmonary injury was evaluated 6 h after LPS challenge. All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of the Adnan Menderes University.
Results:
Methyl palmitate pretreatment significantly attenuated LPS-induced pulmonary histopathologic changes, alveolar hemorrhage, and neutrophil infiltration. Methyl palmitate pretreatment also reduced the concentrations of malondialdehyde in lung tissues.
Conclusions:
This study indicates that methyl palmitate may have a protective effect against LPS-induced acute lung injury, and the potential mechanism of this action may involve the inhibition of NF-κB. activation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP112390	Methyl palmitate		112-39-0	Price

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