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Methylcobalamin: A Potential Vitamin of Pain Killer

Methylcobalamin: A Potential Vitamin of Pain Killer

Ming Zhang, Wenjuan Han, Sanjue Hu, Hui Xu

Neural Plast. 2013;2013:424651.

PMID: 24455309

Abstract:

Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13422554	Methylcobalamin		13422-55-4	Price

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