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Michael Addition of Pyrimidine With Disaccharide Acrylates Catalyzed in Organic Medium With Lipase M From Mucor Javanicus

Hong-Xia Dai, Shi-Ping Yao, Jian Wang

Biotechnol Lett. 2006 Sep;28(18):1503-7.

PMID: 16955356

Abstract:

The Michael addition of fluorouracil (0.01 mol), uracil (0.01 mol), thymine (0.01 mol) to disaccharide acrylates (0.03 mol) was carried out in pyridine (20 ml) at 50 degrees C for 72 h with lipase M from Mucor javanicus (200 mg). Six new pyrimidine derivatives containing a branched sugar were obtained in yields from 56 to 75%.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP9001621-J Lipase from Mucor javanicus Lipase from Mucor javanicus 9001-62-1 Price
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