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Michaelis-Menten Absorption Kinetics in Drugs: - Examples and Implications

Michaelis-Menten Absorption Kinetics in Drugs: - Examples and Implications

J H Wood, K M Thakker

Eur J Clin Pharmacol. 1982;23(2):183-8.

PMID: 7140809

Abstract:

It is shown that the absorption of phenylbutazone, naproxen, and chlorthiazide is governed by a dose limiting mechanism. This dose dependency may be explained by a saturation absorption process mathematically obeying Michaelis-Menten type kinetics. Observed dose relationships for tetracycline, fenclozic acid and related compounds, phenytoin, and possibly digoxin and digitoxin may be explained if a saturable process in absorption is postulated. This behavior may be produced by insolubility of the drug compound, a limited "window of absorption" in the gastrointestinal tract, or a capacity limited absorption because of the carrier or the transport mechanism involved. The need for suitably designed dose response studies with new drug compounds is discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP121302-A	Benzothiadiazine Related Compound A	121-30-2	Price
AP2471707-B	Naproxen Related Compound A	2471-70-7	Price
AP3060502-A	Phenytoin Related Compound A	3060-50-2	Price

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