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Microbe-mediate Transformation of Echinocystic Acid by Whole Cells of Filamentous Fungus Cunninghamella Blakesleana CGMCC 3.910

Shaobin Fu, Xu Feng, Di-An Sun

Mol Biol Rep. 2018 Dec;45(6):2795-2800.

PMID: 30194559

Abstract:

Structural modification of echinocystic acid (EA), a pentacyclic triterpenoid with wide spread biological activities was investigated by microbial transformation. Microbe-mediate transformation of EA was carried out by filamentous fungus Cunninghamella blakesleana CGMCC 3.910. Four metabolites 3β, 7β, 16α-trihydroxy-olean-12-en-28-oic acid (EA-2); 3β, 7β, 16β,19β-tetrahydroxy-olean-12-en-28-oic acid (EA-3); 3β, 7β, 16α, 21β-tetrahydroxy-olean-12-en-28-oic acid (EA-4); 3β, 7β, 16α-trihydroxy-olean-11, 13(18)-dien-28-oic acid (EA-5) were produced. Structures of transformed products were elucidated by 1D and 2D NMR and HR-MS data. EA-3 and EA-4 were new compounds.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP510305 Echinocystic acid Echinocystic acid 510-30-5 Price
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