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Microbial Biosynthesis and Secretion of L-Malic Acid and Its Applications

Microbial Biosynthesis and Secretion of L-Malic Acid and Its Applications

Zhe Chi, Zhi-Peng Wang, Guang-Yuan Wang, Ibrar Khan, Zhen-Ming Chi

Crit Rev Biotechnol. 2016;36(1):99-107.

PMID: 25025277

Abstract:

l-Malic acid has many uses in food, beverage, pharmaceutical, chemical and medical industries. It can be produced by one-step fermentation, enzymatic transformation of fumaric acid to l-malate and acid hydrolysis of polymalic acid. However, the process for one-step fermentation is preferred as it has many advantages over any other process. The pathways of l-malic acid biosynthesis in microorganisms are partially clear and three metabolic pathways including non-oxidative pathway, oxidative pathway and glyoxylate cycle for the production of l-malic acid from glucose have been identified. Usually, high levels of l-malate are produced under the nitrogen starvation conditions, l-malate, as a calcium salt, is secreted from microbial cells and CaCO3 can play an important role in calcium malate biosynthesis and regulation. However, it is still unclear how it is secreted into the medium. To enhance l-malate biosynthesis and secretion by microbial cells, it is very important to study the mechanisms of l-malic acid biosynthesis and secretion at enzymatic and molecular levels.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP97676	L-(−)-Malic acid		97-67-6	Price

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