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Microbial Metabolism Studies of the Antimalarial Drug Arteether

I S Lee, H N ElSohly, C D Hufford

Pharm Res. 1990 Feb;7(2):199-203.

PMID: 2308900

Abstract:

Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized by a number of microorganisms. Large-scale fermentation with Aspergillus niger (ATCC 10549) and Nocardia corallina (ATCC 19070) have resulted in the isolation of four microbial metabolites which have been characterized using two-dimensional nuclear magnetic resonance (2D-NMR) techniques. These metabolites have been identified as "AEM1" (2), 3 alpha-hydroxydeoxyarteether (3), 3 alpha-hydroxydeoxydihydroartemisinin (4), and deoxydihydroartemisinin (5).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1030123900 AEM1 AEM1 1030123-90-0 Price
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