0

Microbial Production of 1α-hydroxyvitamin D3 From Vitamin D3

Safwat A Ahmed, Mostafa K Mesbah, Diaa T Youssef, Sherief I Khalifa

Nat Prod Res. 2014;28(7):444-8.

PMID: 24456427

Abstract:

The microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP41294568 1α-Hydroxyvitamin D3 1α-Hydroxyvitamin D3 41294-56-8 Price
qrcode