Home
Resources
Publications
Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds

Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds

Takashi Ikawa, Shigeaki Masuda, Shuji Akai

Chem Pharm Bull (Tokyo). 2018;66(12):1153-1164.

PMID: 30504631

Abstract:

Fluorinated aromatic compounds are found in a variety of biologically active compounds, including clinical drugs and agrochemicals. Therefore, the synthesis of aryl fluorides is particularly important in the medicinal and process chemistry fields. In this paper, we report a method for the synthesis of aryl fluorides by benzyne fluorination under microflow conditions using the efficient Comet X-01 micromixer. In comparison to our previously reported method under ordinary batch conditions, this approach facilitates a significant reduction in reaction times, to ca. 10 s, as well as increases in the yields of fluoroarenes (by up to 51%).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP108427527	Tetrabutylammonium nonafluorobutanesulfonate		108427-52-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: