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Micronucleus Assay in Human Lymphocytes After Exposure to Alloxydim Sodium Herbicide in Vitro

Micronucleus Assay in Human Lymphocytes After Exposure to Alloxydim Sodium Herbicide in Vitro

Dilek Akyıl, Arzu Özkara, S Feyza Erdoğmuş, Yasin Eren, Muhsin Konuk, Esra Sağlam

Cytotechnology. 2015 Dec;67(6):1059-66.

PMID: 25017922

Abstract:

This study evaluates the cytotoxic and genotoxic potential of alloxydim sodium using micronucleus (MN) assay, in human peripheral lymphocytes. MN assay was used to investigate the genotoxic effects of alloxydim sodium in human peripheral lymphocytes treated with 250, 500, 750, 1,000 µg/ml concentrations of alloxydim sodium for 24 and 48 h. Solvent, negative and positive controls were also used in the experiments in parallel. The obtained results were evaluated in statistical analyses by using Dunnett-t test (two sided) and p < 0.05 was accepted as significant. Alloxydim sodium significantly increased the MN formation compared with the negative control, at both 750 and 1,000 µg/ml concentrations and treatment periods. We also evaluated the nuclear division index (NDI) for cytotoxicity of this pesticide in the experiment, and finally observed a significant decrease of the NDI values at all concentrations of alloxydim sodium and at both treatment periods.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP55635137	Alloxydim-sodium		55635-13-7	Price

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