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MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization

MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization

Pengfei Zhang, Hong Wang, Xueting Luo, Haiyun Liu, Bing Lu, Tong Li, Shiqi Yang, Qing Gu, Bin Li, Fenghua Wang, Xiaodong Sun

Inflammation. 2018 Feb;41(1):143-153.

PMID: 28965281

Abstract:

Arg-1+Ym-1+ M2-type macrophages play essential roles in the development of choroidal neovascularization (CNV). Thus, inhibition of M2-type macrophages may be effective in suppressing CNV. However, the potential mechanisms of macrophage polarization during development of CNV remain unclear. In this study, we report that microRNA-155 (miR-155) inhibited M2 polarization by targeting C/EBPβ in CNV model mice and in bone marrow-derived primary macrophages. Moreover, our data show that intravitreous injection of miR-155 mimics suppressed subretinal leakage and neovascularization. Therefore, we conclude that C/EBPβ plays a significant role in M2 macrophage polarization in CNV model, while miR-155 mimics could suppress CNV by inhibiting C/EBPβ activity and M2 macrophage polarization.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP409086686	YM-1		409086-68-6	Price

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