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MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma

Jianing Yan, Shibo Ying, Xiujun Cai

Biomed Res Int. 2018 Jan 31;2018:2754941.

PMID: 29651425

Abstract:

High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413473 HMGB1/HMG1 human HMGB1/HMG1 human Price
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