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Microwave Assisted Extraction Followed by Gas Chromatography With Tandem Mass Spectrometry for the Determination of Triclosan and Two Related Chlorophenols in Sludge and Sediments

Microwave Assisted Extraction Followed by Gas Chromatography With Tandem Mass Spectrometry for the Determination of Triclosan and Two Related Chlorophenols in Sludge and Sediments

S Morales, P Canosa, I Rodríguez, E Rubí, R Cela

J Chromatogr A. 2005 Aug 5;1082(2):128-35.

PMID: 16035353

Abstract:

A procedure for the determination of 2-(2,4-dichlorophenoxy)-5-chlorophenol (Triclosan) and two possible transformation compounds, 2,4-dichlorophenol (2,4-DCP) and 2,4,6-trichlorophenol (2,4,6-TCP), in sludge from sewage treatment plants (STP) and sediments is presented. Extraction was performed using an acetone:methanol (1:1) mixture under the action of a microwave field. The centrifuged supernatant was diluted with a NaOH aqueous solution and twice extracted with n-hexane for removing neutral and basic interferences. The aqueous layer was acidified and processed as a waste water sample. After concentration analytes were silylated and determined by gas chromatography with tandem mass spectrometry (GC-MS/MS). Influence of experimental conditions on the yield of the extraction process and on the efficiency of the further clean-up step was thoroughly evaluated. Performance of MS/MS detection in comparison to single MS is described. Under final working conditions quantification limits between 0.4 and 0.8 ng/g and recoveries from 78% to 106% were obtained. The method was applied to the analysis of several sludge and sediment samples. Only low levels of TCS were detected in some of the sediments; however, all three compounds were found in sludge samples at concentrations ranging from 7 to 316 ng/g, in the case of chlorophenols, and from 420 to 5400 ng/g, for Triclosan.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31043446	Triclosan Related Compounds Mixture A			Price

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