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MIDA as a Simple and Highly Efficient Ligand for Palladium-Catalyzed Hiyama Cross-Coupling of Aryl Halides

Mengping Guo, Liang Qi, Qiaochu Zhang, Zhiyong Zhu, Wei Li, Xiaogang Li

Org Biomol Chem. 2014 Sep 28;12(36):7136-9.

PMID: 25110916

Abstract:

N-Methyliminodiacetic acid (MIDA) as a simple, air stable and water-soluble ligand has been used in the palladium-catalyzed Hiyama cross-coupling reaction of trimethoxyphenylsilane with aryl halides. The yield of the corresponding Hiyama coupling products is high up to around 90% in water and isopropanol under an ambient atmosphere in the presence of KOH and NaF.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2996921 Trimethoxyphenylsilane Trimethoxyphenylsilane 2996-92-1 Price
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