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Mild Arylboronic Acid Catalyzed Selective [4 + 3] Cycloadditions: Access to Cyclohepta[b]benzofurans and Cyclohepta[b]indoles

Kou-Sen Cao, Hong-Xu Bian, Wen-Hua Zheng

Org Biomol Chem. 2015 Jun 21;13(23):6449-52.

PMID: 25971529

Abstract:

The first example of arylboronic acid catalyzed [4 + 3] cycloaddition reaction is reported. 3,5-Bis-(trifluoromethyl) phenylboronic acid is shown to be the best catalyst in this reaction. The method has also enabled the preparation of cyclohepta[b]benzofurans and cyclohepta[b]indoles in excellent yields.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP128796394 4-(Trifluoromethyl)phenylboronic acid 4-(Trifluoromethyl)phenylboronic acid 128796-39-4 Price
AP73852194 3,5-Bis(trifluoromethyl)phenylboronic acid 3,5-Bis(trifluoromethyl)phenylboronic acid 73852-19-4 Price
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