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Mild Double Allylboration Reactions of Nitriles and Acid Anhydrides Using Potassium Allyltrifluoroborate

Timothy R Ramadhar, Jazmin Bansagi, Robert A Batey

J Org Chem. 2013 Feb 1;78(3):1216-21.

PMID: 23214971

Abstract:

The double allylboration of nitriles and acid anhydrides to form bis-allyl amines and esters, respectively, can be achieved through the use of potassium allyltrifluoroborate in the presence of boron trifluoride etherate at room temperature. The method described is relatively mild, exhibits chemoselectivity to other electrophiles present, avoids the use of metals, and features the use of an operationally stable and robust potassium organotrifluoroborate reagent.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP233664534 Potassium allyltrifluoroborate Potassium allyltrifluoroborate 233664-53-4 Price
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