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Minoxidil-encapsulated poly(L-lactide-co-glycolide) Nanoparticles With Hair Follicle Delivery Properties Prepared Using W/O/W Solvent Evaporation and Sonication

Minoxidil-encapsulated poly(L-lactide-co-glycolide) Nanoparticles With Hair Follicle Delivery Properties Prepared Using W/O/W Solvent Evaporation and Sonication

Issei Takeuchi, Yukari Hida, Kimiko Makino

Biomed Mater Eng. 2018;29(2):217-228.

PMID: 29457595

Abstract:

Background:
Nanoparticles with a diameter of 100-150 nm prepared using poly(lactide-co-glycolide) can be delivered to hair follicles. Moreover, it was shown that drug release from nanoparticles was prolonged by using poly(L-lactide-co-glycolide) (PLLGA).
Objective:
The aim of this study was to prepared minoxidil-encapsulated PLLGA nanoparticles and accumulate minoxidil in hair follicles utilizing its drug delivery properties for effective treatment of male and female androgenetic alopecia.
Methods:
Minoxidil-encapsulated PLLGA nanoparticles were prepared using W/O/W solvent evaporation and sonication, and the ability of PLLGA nanoparticles to deliver to hair follicles was evaluated by in vivo transdermal delivery study using C3H/He mice and tape stripping and cyanoacrylate skin surface biopsy.
Results:
Eight hours after administration of samples, minoxidil-encapsulated PLLGA nanoparticles delivered 3.1 times more minoxidil in stratum corneum and 2.5 times more in hair follicles r compared to minoxidil aqueous solution. In addition, we found that 4.8% of the dose of minoxidil-encapsulated PLLGA nanoparticles were delivered to the hair follicles.
Conclusions:
In this study, it was shown that nanoparticulation using PLLGA7510 suppressed minoxidil release from nanoparticles and improved drug delivery amount to hair follicles.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74383	Poly(L-lactide-co-glycolide)			Price

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