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miR-29a Attenuates Cardiac Hypertrophy Through Inhibition of PPARδ Expression

miR-29a Attenuates Cardiac Hypertrophy Through Inhibition of PPARδ Expression

Si Zhang, Zhongnan Yin, Fei-Fei Dai, Hao Wang, Meng-Jiao Zhou, Ming-Hui Yang, Shu-Feng Zhang, Zhi-Feng Fu, Ying-Wu Mei, Ming-Xi Zang, Lixiang Xue

J Cell Physiol. 2019 Aug;234(8):13252-13262.

PMID: 30580435

Abstract:

Although cardiac hypertrophy is widely recognized as a risk factor that leads to cardiac dysfunction and, ultimately, heart failure, the complex mechanisms underlying cardiac hypertrophy remain incompletely characterized. The nuclear receptor peroxisome proliferator-activated receptor δ (PPARδ) is involved in the regulation of cardiac lipid metabolism. Here, we describe a novel PPARδ-dependent molecular cascade involving microRNA-29a (miR-29a) and atrial natriuretic factor (ANF), which is reactivated in cardiac hypertrophy. In addition, we identify a novel role of miR-29a, in which it has a cardioprotective function in isoproterenol hydrochloride-induced cardiac hypertrophy by targeting PPARδ and downregulating ANF. Finally, we provide evidence that miR-29a reduces the isoproterenol hydrochloride-induced cardiac hypertrophy response, thereby underlining the potential clinical relevance of miR-29a in which it may serve as a potent therapeutic target for heart hypertrophy treatment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51309-A	Isoproterenol hydrochloride		51-30-9	Price
AP5984952	(−)-Isoproterenol hydrochloride		5984-95-2	Price

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