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Mitochondrial Damage Following Exposure of Organotypic Cultures of Human Malignant Gliomas to 2-chloro- And 2-bromo-2'-deoxyadenosine

Mitochondrial Damage Following Exposure of Organotypic Cultures of Human Malignant Gliomas to 2-chloro- And 2-bromo-2'-deoxyadenosine

E Matyja, P Grieb, M Ryba, J Jagielski, M J Mossakowski

Folia Neuropathol. 1996;34(1):31-9.

PMID: 8855085

Abstract:

The effects of 2-chloro-2'-deoxyadenosine (cladribine, 2-CdA) and a closely related compound 2-bromo-2'-deoxyadenosine (2-BdA) on organotypic cultures of human malignant gliomas were studied with the use of electron microscopy. The cultures grown from surgical biopsies included six glioblastomas, three anaplastic astrocytomas and low-grade fibrillary astrocytoma. After 6 to 10 days of the in vitro growth the cultures were exposed to 0.3-10 microM 2-CdA or 2-BdA for 1 to 10 days. Mitochondrial swelling and disappearance of cristae following exposure to the tested substances were observed, but only in highly anaplastic (low-differentiated) tumor cells. The mitochondrial toxicity was dose- and time-dependent, and no difference was found between the effect of 2-CdA and 2-BdA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24757708	Cladribine Related Compound A		24757-70-8	Price

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