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Mitochondrial Regulator PGC-1a-Modulating the Modulator

Mitochondrial Regulator PGC-1a-Modulating the Modulator

Karl N Miller, Josef P Clark, Rozalyn M Anderson

Curr Opin Endocr Metab Res. 2019 Mar;5:37-44.

PMID: 31406949

Abstract:

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a central regulator of metabolism that is poised at the intersection of myriad intracellular signaling pathways. In this brief update, we discuss regulation of PGC-1a at multiple levels, including transcriptional, post-transcriptional, and post-translational modifications. We discuss recently identified small molecule effectors of PGC-1a that offer translational potential and promise new insight into PGC-1a biology. We highlight novel mechanistic insights relating to PGC-1a's interactions with RNA to enhance transcription and potentially influence transcript processing. Finally, we place these exciting new data in the context of aging biology, offering PGC-1a as a candidate target with terrific potential in anti-aging interventions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1642375663	Bepristat 1a		1642375-66-3	Price

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