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Mixing Ginkgo Biloba Extract With Sesame Extract and Turmeric Oil Increases Bioavailability of Ginkgolide A in Mice Brain

Mixing Ginkgo Biloba Extract With Sesame Extract and Turmeric Oil Increases Bioavailability of Ginkgolide A in Mice Brain

Kazuko Iwamoto, Hirokazu Kawamoto, Fumiaki Takeshita, Shinichi Matsumura, Ikuto Ayaki, Tatsuya Moriyama, Nobuhiro Zaima

J Oleo Sci. 2019 Sep 4;68(9):923-930.

PMID: 31413248

Abstract:

Ginkgo biloba extract (GBE) is widely used as herbal medicine. Preventive effect of GBE against dementia, including Alzheimer's disease, has been reported. The bioactive compounds in GBE that impart these beneficial effects, flavonoids and terpene lactones, have poor bioavailability. Our previous study found distribution of bioactive compounds of sesame extract in mice brain after mixing it with turmeric oil. Here, we evaluate the distribution of bioactive compounds of GBE by combining it with the mixture of sesame extract and turmeric oil (MST). The content of terpene lactones in mice serum was significantly increased in a dose-dependent manner after administration of GBE. However, the contents of terpene lactones in mice brain were not significantly changed. Concentration of ginkgolide A in mice brain increased significantly when GBE was co-administrated with MST than when GBE was administered alone. These results suggest that MST may be effective in enhancing the bioavailability of ginkgolide A in GBE.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15291755	Ginkgolide A		15291-75-5	Price

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