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Mode of Action of the Antimicrobial Compound 5-bromo-5-nitro-1,3-dioxane (Bronidox)

Mode of Action of the Antimicrobial Compound 5-bromo-5-nitro-1,3-dioxane (Bronidox)

M Ghannoum, M Thomson, W Bowman, S Al-Khalil

Folia Microbiol (Praha). 1986;31(1):19-31.

PMID: 3082729

Abstract:

The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC testing, thiol inhibition of activity, intracellular leakage, oxygen consumption, incorporation of 3H-uridine, scanning electron microscopy, inhibition of enzyme activity (papain) and in vitro oxidation of thiols to disulfides. It appears that the primary mode of action of bronidox is the same as, or similar to, that of bronopol, i.e. the oxidation of essential protein thiol causing inhibition of enzyme activity and subsequent inhibition of microbial growth.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30007477	5-Bromo-5-nitro-1,3-dioxane		30007-47-7	Price

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