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Models of Binding of 4'-nitrophenyl alpha-D-mannopyranoside to the Lectin Concanavalin A

Models of Binding of 4'-nitrophenyl alpha-D-mannopyranoside to the Lectin Concanavalin A

S J Hamodrakas, E Alexandraki, A Troganis, C I Stassinopoulou

Int J Biol Macromol. 1989 Feb;11(1):17-22.

PMID: 2489052

Abstract:

Molecular models for the complex formed between the lectin concanavalin A (Con A) and the saccharide derivative 4'-nitrophenyl-alpha-D-mannopyranoside (alpha-PNM) are presented, combining evidence from 1H-n.m.r. measurements, semi-empirical energy calculations and interactive graphics modelling. The models are in good agreement with the experimental data. Close examination of the models suggests that hydrophobic interactions together with van der Waals interactions and hydrogen bonds contribute to the stability of the complexes. It appears that there is a limited number of possible modes of binding of alpha-PNM to Con A.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10357274	4-Nitrophenyl α-D-mannopyranoside		10357-27-4	Price

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