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Molecular Enantiorecognition of L-Glucose and D-Glucose in Whole Blood Samples

Molecular Enantiorecognition of L-Glucose and D-Glucose in Whole Blood Samples

Raluca-Ioana Stefan-van Staden, Grigorina Mitrofan

Chirality. 2018 May;30(5):680-685.

PMID: 29498440

Abstract:

In the past years, enantioanalysis became very important for clinical analysis; biomarkers/substances of biomedical importance with chiral structure should be analyzed and their presence correlated with the specific disorder. Therefore, we developed a method for the assay of l- and d-glucose, based on molecular recognition of l- and d-glucose. While for d-glucose there are many methods to assess its quantity, the l-enantiomer is not routinely detected by standard methods. Two stochastic microsensors based on the immobilization of Copper(II)phthalocyanine and Ni(II)phthalocyanine, in natural diamond powder, were proposed for the enantioanalysis of glucose. The proposed methods proved to have high sensitivities and were able to be used for determination of concentrations as low as 2.5 pg mL-1 for d-glucose and as low as 2.5 fg mL-1 for l-glucose. The enatioanalysis was performed with good results in whole blood samples collected from diabetic patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP147148-A	Copper(II) phthalocyanine		147-14-8	Price

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