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Molecular Pathogenesis of Klebsiella Pneumoniae

Molecular Pathogenesis of Klebsiella Pneumoniae

Bei Li, Yuling Zhao, Changting Liu, Zhenhong Chen, Dongsheng Zhou

Future Microbiol. 2014;9(9):1071-81.

PMID: 25340836

Abstract:

Typical Klebsiella pneumoniae is an opportunistic pathogen, which mostly affects those with weakened immune systems and tends to cause nosocomial infections. A subset of hypervirulent K. pneumoniae serotypes with elevated production of capsule polysaccharide can affect previously healthy persons and cause life-threatening community-acquired infections, such as pyogenic liver abscess, meningitis, necrotizing fasciitis, endophthalmitis and severe pneumonia. K. pneumoniae utilizes a variety of virulence factors, especially capsule polysaccharide, lipopolysaccharide, fimbriae, outer membrane proteins and determinants for iron acquisition and nitrogen source utilization, for survival and immune evasion during infection. This article aims to present the state-of-the-art understanding of the molecular pathogenesis of K. pneumoniae.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7413107	Lipopolysaccharides from Klebsiella pneumoniae			Price

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