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Molecular Structure and Stability of Perindopril Erbumine and Perindopril L-arginine Complexes

Molecular Structure and Stability of Perindopril Erbumine and Perindopril L-arginine Complexes

Milan Remko

Eur J Med Chem. 2009 Jan;44(1):101-8.

PMID: 18436349

Abstract:

The methods of theoretical chemistry have been used to elucidate molecular properties of the antihypertensive, cardiovascular protective and antithrombotic perindopril ((2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid). The geometries and energies of various neutral and ionized complexes of perindopril erbumine and perindopril l-arginine have been computed using HF/6-31G(d) and Becke3LYP/6-31G(d) methods. The calculations showed that in both, the isolated state and water solution perindopril erbumine exists as a neutral complex. In the gas-phase perindopril l-arginine both neutral and ionic complexes are, at the HF level of theory, almost equally stable. The B3LYP level of theory slightly favors single proton transfer complex perindopril l-arginine (by about 14 kJ mol(-1)). In polar solvents like water, the ionized form of perindopril l-arginine becomes much more favored. According to our calculations l-arginine is bound to perindopril more strongly (by about 25 kJ mol(-1)) than erbumine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107133368	Perindopril erbumine		107133-36-8	Price

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