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Mono-butyl Phthalate-Induced Mouse Testis Injury Is Associated With Oxidative Stress and Down-Regulated Expression of Sox9 and Dazl

Mono-butyl Phthalate-Induced Mouse Testis Injury Is Associated With Oxidative Stress and Down-Regulated Expression of Sox9 and Dazl

Junting Du, Di Xiong, Qian Zhang, Xiaoxiao Li, Xudong Liu, Huihui You, Shumao Ding, Xu Yang, Junlin Yuan

J Toxicol Sci. 2017;42(3):319-328.

PMID: 28496037

Abstract:

Mono-butyl phthalate (MBP) has reproductive toxicity but the related mechanisms have not been fully elucidated in vivo. We exposed male Balb/c mice to MBP by gavage at doses of 0, 25, 50, 100, 200 mg/kg for 14 days, and then evaluated the testicular alterations at the histological and molecular levels. MBP reduced mouse sperm count along with sperm malformation and seminiferous tubule degeneration in a dose-dependent manner. MBP dosed at 200 mg/kg significantly increased reactive oxygen species and malondialdehyde content in mouse testes. High doses of MBP (200 mg/kg) also significantly reduced mRNA expressions of testis growth and function related genes (Sox9 and Dazl). Our findings suggest that oxidative stress and down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP131704	mono-Butyl phthalate		131-70-4	Price

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