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Monotropein Attenuates Ovariectomy and LPS-induced Bone Loss in Mice and Decreases Inflammatory Impairment on Osteoblast Through Blocking Activation of NF-κB Pathway

Monotropein Attenuates Ovariectomy and LPS-induced Bone Loss in Mice and Decreases Inflammatory Impairment on Osteoblast Through Blocking Activation of NF-κB Pathway

Yu-Qiong He, Hua Yang, Yi Shen, Jian-Hua Zhang, Zhi-Guo Zhang, Lin-Lin Liu, Hong-Tao Song, Bin Lin, Hsien-Yeh Hsu, Lu-Ping Qin, Ting Han, Hai-Liang Xin, Qiao-Yan Zhang

Chem Biol Interact. 2018 Aug 1;291:128-136.

PMID: 29908987

Abstract:

Estrogen deficiency and inflammation are known to play important roles in bone metabolism and occurrence of osteoporosis. Monotropein as an iridoid glycoside is reported to decrease estrogen deficiency-induced bone loss and inhibit inflammatory response in LPS-induced RAW 264.7 macrophages. However, the effect of monotropein on bone loss in chronic inflammatory conditions remains unclear. It was found in the present study that monotropein significantly inhibited bone mass reduction and improved bone micro-architectures by enhancing bone formation and blocking increased secretion of inflammatory cytokines in osteoporotic mice induced by combined ovariectomy and LPS. Our in vitro experiment further demonstrated that monotropein was able to increase the proliferation and activity of alkaline phosphatase (ALP), bone matrix mineralization and the expression of bone matrix protein osteopontin (OPN) in osteoblastic MC3T3-E1 cells injured by LPS. In addition, monotropein significantly decreased the production of IL-6 and IL-1β, inhibited the nuclear translocation of p65 and NF-κB P50, and down-regulated the phosphorylation of NF-κB p65 and IKK, indicating that monotropein could attenuate inflammatory impairment to MC3T3-E1 cells by suppressing the activation of NF-κB pathway. All these results suggest that monotropein may prove to be a promising candidate for the prevention and treatment of inflammatory bone loss.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5945506	Monotropein		5945-50-6	Price

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