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Monotropein Exerts Protective Effects Against IL-1β-induced Apoptosis and Catabolic Responses on Osteoarthritis Chondrocytes

Monotropein Exerts Protective Effects Against IL-1β-induced Apoptosis and Catabolic Responses on Osteoarthritis Chondrocytes

Feng Wang, Longhuo Wu, Linfu Li, Siyi Chen

Int Immunopharmacol. 2014 Dec;23(2):575-80.

PMID: 25466264

Abstract:

Osteoarthritis, characterized by a loss of articular cartilage accompanied with inflammation, is the most common age-associated degenerative disease. Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity. In the present study, monotropein was firstly to exhibit cartilage protective activity by down regulating the pro-inflammatory cytokines in the knee synovial fluid in vivo. The anti-apoptotic and anti-catabolic effects of monotropein on rat OA chondrocytes treated by IL-1β were investigated in vitro. In cultured chondrocytes, monotropein attenuated apoptosis in a dose-dependent manner in response to IL-1β stimulation. Moreover, treatment with monotropein, the expressions of MMP-3 and MMP-13 were significantly decreased, the expression of COL2A1 was increased. Taken together, these findings suggested that monotropein exerted anti-apoptosis and anti-catabolic activity in chondrocytes, which might support its possible therapeutic role in OA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5945506	Monotropein		5945-50-6	Price

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