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Monotropein Isolated From the Roots of Morinda Officinalis Ameliorates Proinflammatory Mediators in RAW 264.7 Macrophages and Dextran Sulfate Sodium (DSS)-induced Colitis via NF-κB Inactivation

Monotropein Isolated From the Roots of Morinda Officinalis Ameliorates Proinflammatory Mediators in RAW 264.7 Macrophages and Dextran Sulfate Sodium (DSS)-induced Colitis via NF-κB Inactivation

Ji-Sun Shin, Kyung-Jin Yun, Kyung-Sook Chung, Kyeong-Hwa Seo, Hee-Juhn Park, Young-Wuk Cho, Nam-In Baek, Daesik Jang, Kyung-Tae Lee

Food Chem Toxicol. 2013 Mar;53:263-71.

PMID: 23261679

Abstract:

We previously demonstrated that monotropein isolated from the roots of Morinda officinalis (Rubiaceae) has anti-inflammatory effects in vivo. In the present study, we investigated the molecular mechanisms underlying the anti-inflammatory effects of monotropein in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein was found to inhibit the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) mRNA in LPS-induced RAW 264.7 macrophages. Treatment with monotropein decreased the DNA binding activity of nuclear factor-κB (NF-κB). Consistent with these findings, monotropein also suppressed phosphorylation and degradation of inhibitory κB-α (IκB-α), and consequently the translocations of NF-κB. In the DSS-induced colitis model, monotropein reduced disease activity index (DAI), myeloperoxidase (MPO) activity, and inflammation-related protein expressions by suppressing NF-κB activation in colon mucosa. Taken together, these findings suggest that the anti-inflammatory effects of monotropein are mainly related to the inhibition of the expressions of inflammatory mediators via NF-κB inactivation, and support its possible therapeutic role in colitis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5945506	Monotropein		5945-50-6	Price

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