Home
Resources
Publications
Mouse Splenocyte Blast Transformation in the Presence of Plasma γ-globulin Fraction Proteins and Their Complexes With Copper and Zinc

Mouse Splenocyte Blast Transformation in the Presence of Plasma γ-globulin Fraction Proteins and Their Complexes With Copper and Zinc

S B Cheknev, E A Grigorjeva, T N Nikolaeva, A V Pronin

Bull Exp Biol Med. 2011 Mar;150(5):624-6.

PMID: 22235400

Abstract:

Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by these cations and human serum γ-globulin induce blast transformation of splenocytes from BALB/c mice at a level comparable to that induced by concanavalin A. Zinc bound to γ-globulin reduces by 25% and copper in complex with this protein stimulates by 1.6 times its capacity to induce blast transformation. Combinations with concanavalin A reproduce the effects of γ-globulin-metal complex under conditions of mitogen induction. Incorporation of(3)H-thymidine in splenocytes incubated with combinations of γ-globulin-copper metalcomplex, copper cations, and control protein with concanavalin A was by 1.4, 1.3 (p<0.1), and 1.25 times higher (p<0.05), respectively, than after incubation with concanavalin A alone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9007834-B	γ-Globulins from mouse		9007-83-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: