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Multi-residue Analysis of Veterinary Drugs, Pesticides and Mycotoxins in Dairy Products by Liquid Chromatography-Tandem Mass Spectrometry Using Low-Temperature Cleanup and Solid Phase Extraction

Multi-residue Analysis of Veterinary Drugs, Pesticides and Mycotoxins in Dairy Products by Liquid Chromatography-Tandem Mass Spectrometry Using Low-Temperature Cleanup and Solid Phase Extraction

Jie Xie, Tao Peng, Ailing Zhu, Jianli He, Qiaoying Chang, Xueyan Hu, Hui Chen, Chunlin Fan, Wenxiao Jiang, Min Chen, Jiancheng Li, Shuangyang Ding, Haiyang Jiang

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:19-29.

PMID: 26298066

Abstract:

A multi-class multi-residue analysis method for determination of veterinary drugs, pesticides and mycotoxins in dairy products by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been established. These 17 classes, a total of 40 kinds of target compounds were chosen because their administration to food-producing animals is banned or regulated in China and may be potentially abused or misused. Samples were extracted with acetonitrile-ethyl acetate-acetic acid (49.5+49.5+1, v/v/v). Most of lipids in the extract were removed by low-temperature cleanup, prior to solid phase extraction on HLB cartridges. The quantification and confirmation of the 40 analytes were performed by LC-MS/MS with electro-spray ionization (ESI) interface in multiple reaction monitoring (MRM) mode. The limits of detection (LODs) and limits of quantification (LOQs) were 0.006-0.3μg/kg and 0.02-1.0μg/kg, respectively. The spiked recoveries in milk, yogurt, milk powder and cheese samples were from 67.3% to 106.9%. The repeatability and the within-laboratory reproducibility were less than 12.7% and 13.9%. Applying this method, our results revealed the presences of chloramphenicol, cimeterol, and flunixin at the concentration of 0.027-0.452μg/kg in some samples.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121476	Spiked milk powder (pesticides)			Price

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