Home
Resources
Publications
Muscarinic Receptor Binding Activity of Polyoxygenated Flavones From Melicope Subunifoliolata

Muscarinic Receptor Binding Activity of Polyoxygenated Flavones From Melicope Subunifoliolata

L Y Chung, K F Yap, S H Goh, M R Mustafa, Z Imiyabir

Phytochemistry. 2008 May;69(7):1548-54.

PMID: 18334259

Abstract:

The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1); melisimplexin (3); 3,3',4',5,7-pentamethoxyflavone (4); meliternatin (5); 3,5,8-trimethoxy-3',4',6,7-bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)] were isolated from the bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. The methoxyflavones (compounds 1, 3, 4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive. The potency of the methoxyflavones to inhibit [(3)H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7437550	8-Geranyloxypsoralen		7437-55-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: