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Muscimol as an Ionotropic GABA Receptor Agonist

Muscimol as an Ionotropic GABA Receptor Agonist

Graham A R Johnston

Neurochem Res. 2014 Oct;39(10):1942-7.

PMID: 24473816

Abstract:

Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(®)) and 4-PIOL.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP145821609	Tiagabine Related Compound A		145821-60-9	Price

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