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Muscone Ameliorates Diabetic Peripheral Neuropathy Through Activating AKT/mTOR Signalling Pathway

Muscone Ameliorates Diabetic Peripheral Neuropathy Through Activating AKT/mTOR Signalling Pathway

Jie Dong, Hua Li, Yang Bai, Cong Wu

J Pharm Pharmacol. 2019 Nov;71(11):1706-1713.

PMID: 31468549

Abstract:

Objectives:
Emerging evidence showed that muscone could improve chronic inflammation after myocardial infarction and protect alcohol-induced osteonecrosis of the femoral head. However, the function of muscone on diabetic peripheral neuropathy (DPN) is obscure.
Methods:
The neuronal Schwann cell RSC 96 cells were treated with 125 mmol/l glucose to simulate the cells in DPN. The RSC 96 cell viability was detected by cell counting kit-8. The RSC 96 cell cycle and apoptosis were determined by flow cytometry. The expression of marker proteins of apoptosis, autophagy and AKT/mTOR signalling pathway was assessed by Western blot.
Key findings:
We observed that after high glucose (HG) treatment, the number of cell apoptosis was increased, cell proliferation was decreased, as well as the expression of apoptosis-related proteins and autophagy-related proteins were changed. However, this phenomenon can be reversed by muscone. Meanwhile, the expression of phosphorylated AKT and mammalian target of rapamycin (mTOR) was down-regulated with HG treatment, while the expression quantity was up-regulated after disposed with muscone.
Conclusions:
Our outcomes demonstrated that autophagy and apoptosis of RSC 96 cells induced by HG can be alleviated by muscone through modulating AKT/mTOR signalling pathway, suggesting that muscone might be a potential molecule with influence in connection to DPN.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP541913	Muscone		541-91-3	Price

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