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Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and Its Metabolites in Short-Term Tests in Vitro

Mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and Its Metabolites in Short-Term Tests in Vitro

A Matsuoka, M Matsui, N Miyata, T Sofuni, M Ishidate Jr

Mutat Res. 1990 Jun;241(2):125-32.

PMID: 2345551

Abstract:

The mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites was investigated in the reverse mutation assay using S. typhimurium strains and the chromosomal aberration test in vitro using a Chinese hamster fibroblast cell line, CHL. BHA, tert-butylhydroquinone (BHQ), tert-butylquinone (BQ) and BHA dimer (diBHA) did not show any mutagenic potential with and without S9 mix in the reverse mutation assay. In addition to the above 4 chemicals, 3-tert-butyl-4,5-dihydroxyanisole (BHA-OH), 3-tert-butylanisole-4,5-quinone (BHA-o-Q), and tert-butylquinone oxide (BQO) were tested in the chromosomal aberration test. BHA, BHQ and BQ induced chromosomal aberrations only in the presence of S9 mix, while BHA-OH, BHA-o-Q and BQO induced chromosomal aberrations only without S9 mix. DiBHA, however, showed no clastogenic potential with and without S9 mix. The present findings suggest that BHA-OH, BHA-o-Q or BQO may contribute to the clastogenicity of BHA in the presence of S9 mix.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP121006-A	3-tert-Butyl-4-hydroxyanisole		121-00-6	Price

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