Home
Resources
Publications
Myocardial Actions of Milrinone: Characterization of Its Mechanism of Action

Myocardial Actions of Milrinone: Characterization of Its Mechanism of Action

S T Rapundalo, I Grupp, G Grupp, M Abdul Matlib, R J Solaro, A Schwartz

Circulation. 1986 Mar;73(3 Pt 2):III134-44.

PMID: 2417746

Abstract:

The effect of milrinone on hemodynamic, pharmacologic, and key metabolic processes involved in regulating myocardial cellular calcium was evaluated in an attempt to characterize the mechanism of action of this compound. Data from open-chest dog preparations and isolated guinea pig and rat heart preparations showed that milrinone causes a significant increase in contractility (+ dP/dt of left ventricular pressure) and coronary blood flow. Based on evidence from the Langendorff heart preparations, this positive inotropic effect of milrinone may be related in part to the drug's significant effect on positive chronotropy. However, the coronary-dilating action by milrinone appears to be direct and independent of positive chronotropy. Biochemical studies demonstrated that milrinone appears to have little effect on cardiac subcellular Ca++ transport systems. Preliminary findings indicate, however, that milrinone may play a role in initiating an earlier spontaneous release of Ca++ from the sarcoplasmic reticulum. The implications of these and other results in relation to the drug's mechanism of action are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80047241	Milrinone Related Compound A		80047-24-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: