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Myocardial Effects of Calcium Cyclamate in the BIO F1D Alexander Syrian Golden Hamster

Myocardial Effects of Calcium Cyclamate in the BIO F1D Alexander Syrian Golden Hamster

H Ernst, S Rittinghausen, B Bellmann, Z X Xie, U Mohr

Exp Pathol. 1988;34(1):23-7.

PMID: 2465174

Abstract:

In a subchronic 90-day oral toxicity study, 5 groups (20 males, 20 females each) of F2-descendants of BIO F1D Alexander hamsters received 0, 275, 550, 1,100 and 2,200 mg/kg b.w./day doses, respectively, of calcium cyclamate in the drinking water. These doses caused no adverse health effects in any treated animal and the multifocal myocardial calcifications, detectable at a 100% incidence in the male and female control hamsters (20 males, 20 females), were not exacerbated by the sweetener. Instead, the myocardial lesions exhibited a striking negative dose-response relationship with a 0% incidence in the males and a 5% incidence in the female hamsters of the highest dose group.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5897165	Calcium cyclamate		5897-16-5	Price

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