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Myricitrin Attenuates Memory Impairment in a Rat Model of Sepsis-Associated Encephalopathy via the NLRP3/Bax/Bcl Pathway

Myricitrin Attenuates Memory Impairment in a Rat Model of Sepsis-Associated Encephalopathy via the NLRP3/Bax/Bcl Pathway

Junzuo Gong, Shu Luo, Shiqiao Zhao, Songlin Yin, Xiaofeng Li, Tianyi Mou

Folia Neuropathol. 2019;57(4):327-334.

PMID: 32337945

Abstract:

Introduction:
The present investigation determined the protective effect of myricitrin against sepsis-associated encephalopathy in rats.
Material and methods:
Sepsis was induced by cecal ligation and puncture (CLP); rats were treated with 30 or 100 mg/kg of myricitrin for 5 days prior to the induction of CLP. The effect of myricitrin was observed by determining the neurological function using the open field test and step-down inhibitory avoidance test. Cerebral oedema and the levels of inflammatory and oxidative stress mediators were determined in brain tissues. Moreover, the expression levels of Bcl-2, Bax, IκB-α, nuclear factor κB (NF-κB), caspase-3 and NLRP3 were estimated in brain tissues by Western blotting and the mRNA expression of NF-κB, caspase-3 and NLRP3 in brain tissues was estimated by real-time polymerase chain reaction. An immunofluorescence assay was performed to estimate inflammasome activity.
Results:
The results suggest that treatment with myricitrin protects neuronal function in rats with CLP-induced sepsis. Decreases in inflammation and oxidative stress mediators were observed in the brain tissues of the myricitrin-treated group compared to the CLP group. Moreover, treatment with myricitrin ameliorated the altered Bcl-2, Bax, IκB-α, NF-κB, caspase-3 and NLRP3 protein and mRNA expression levels in the brain tissues of septic rats.
Conclusions:
The data reveal that myricitrin ameliorated neuroinflammation and improved memory in rats with CLP-induced sepsis by regulating the NLRP3/Bax/Bcl signalling pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17912877	Myricitrin		17912-87-7	Price

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